Department of  Neurosurgery
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Yano Lab

Yano Lab

Hiroko Yano, PhD

The Yano Laboratory is in the Department of Neurological Surgery at Washington University School of Medicine and is affiliated with the Departments of Neurology and Genetics. Our laboratory aims to identify molecular mechanisms of neurodegeneration in neurological disorders, in particular, in Huntington’s disease (HD), a progressive and fatal neurodegenerative disease with no effective treatment to date. Using primary neuron and mouse models of the disease, we are trying to understand how selective neurons in the brain become dysfunctional and die in HD through various approaches, including molecular biology, cell biological, biochemistry, and genetics. Our ultimate goal is to discover new therapeutic strategies targeting disease-specific molecular changes to prevent neurodegeneration in human HD and potentially other neurodegenerative disorders.

Current Research

Lab Team