Current Research — Limbrick Lab
In our laboratory, we focus on cerebrospinal fluid physiology, both under normal conditions and in pathological states such as hydrocephalus and syringomyelia.
We have built two main study lines unified by disturbances in cerebrospinal (CSF) hydrodynamics. The first study line focuses on hydrocephalus, specifically post-hemorrhagic hydrocephalus of prematurity and congenital hydrocephalus. Our translational research efforts are directed toward characterizing CSF markers of hydrocephalus and evaluating protein mediators of neurodevelopment. In partnership with the Hydrocephalus Clinical Research Network (HCRN), we have developed a multi-institutional CSF repository to facilitate the study of CSF biomarkers with detailed clinical and neurodevelopmental data.
Our second study line, primarily a clinical and image-based research project, focuses on syringomyelia associated with Chiari type I malformation (CM+SM). With generous philanthropic support, we have created the Park-Reeves Syringomyelia Research Consortium (PRSRC), a 28-center North American research collaboration designed to identify the best neurosurgical practices for the treatment of CM+SM.
For both the hydrocephalus and Chiari-associated syringomyelia study lines, we are actively engaged in the application of novel and advanced imaging techniques, such as MRI diffusion tensor imaging, resting state functional connectivity, elastography, cine phase contrast, and TRUE FISP to better understand the pathophysiology of both conditions.