Department of  Neurosurgery
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Grants & Clinical Trials by Area

 

Increase in number of departmental grants over the past 15+ years

Tumors
Current Grants:

“The Effect of Checkpoint Blockade Immunotherapy on Malignant Glioma Immunogenicity” – Gavin Dunn
Siteman ACS-IRG
01/01/15 – 12/31/15
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“Immunobiology of Malignant Glioma” – Gavin Dunn
NIH K08
07/01/15 – 06/30/20
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“Mechanisms of Radiation Resistance in Brain Meningiomas” – Albert Kim
Meningioma Mommas
06/01/15 – 05/31/16
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“Therapeutic epigenetic reprogramming of brain cancer stem cells using microRNAs” – Albert Kim
Brain Research Foundation
06/01/15 – 05/31/17
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“Regulation of Brain Cancer Stem Cells by the Anaphase-Promoting Complex” – Albert Kim
Concern Foundation
07/01/14 – 06/30/16
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“Mechanisms of Dendrite Morphogenesis by the Anaphase-Promoting Complex” – Albert Kim
NIH K08
9/1/2012 – 7/31/2017
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Current Clinical Trials:
“Prospective Multicenter Cohort Study Comparing Extent of Tumor Resection Between Microscopic Transsphenoidal Surgery and Fully Endoscopic Transsphenoidal Surgery for Nonfunctioning Pituitary Adenomas” – Michael Chicoine

“Transsphenoidal Extent of Resection Study (TRANSSPHER)” – Michael Chicoine
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“I-MiND: IMRIS Intraoperative iMRI Neurosurgical Database” – Michael Chicoine

“MSTIE III: Minimally Invasive Surgery Plus rt-PA for Intracerebral Hemorrhage Evacuation” – Michael Chicoine
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“Neoepitope-based Personalized Vaccine Approach in Patients With Newly Diagnosed Glioblastoma”Gavin Dunn
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Spine
Current Grants:

 “An Implantable Transient Electronic Nerve Stimulation Device based on Transient Electronics”
DARPA subcontract with Transient Electronics – Zack Ray
11/18/14 – 02/17/17
 
“Development of a macro-sieve interface for chronic communication in the primate peripheral nervous system” – Zack Ray
DARPA (PI: Moran)
03/31/15 – 03/31/18
 
“Nerve Transfers for Improved Hand Function following Cervical Spinal Cord Injury” – Zack Ray
Department of Defense
08/15/15 – 08/14/19
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“Evaluation of Axonal Integrity Using Diffusion Tensor Imaging” – Zack Ray
NIH K23
09/01/13-08/31/18       
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“Diffusion basis spectrum imaging predicts neuroinflammation and axonal loss in acute and chronic spinal cord injury” – Zack Ray
University of Missouri Spinal Cord Injury Research Program
10/01/15-09/30/17                     

Current Clinical Trials:
“Restoring Hand Function Using Nerve Transfers in Persons with Spinal Cord Injury” – Zack Ray

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“A Phase IIB, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Staphylococcus Aureus 4-Antigen Vaccine (SA4Ag) in Adults Undergoing Elective Posterior Instrumented Lumbar Spinal Fusion Procedures” – Zack Ray

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“Safety and Efficacy of Pulsed Electromagnetic Fields (Cervical-Stim) as an Adjunct to Enhance Union in Conservatively Treated Type II Fractures of the Odontoid Process” – Zack Ray

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 “Diffusion Tensor Imaging to Assess the Functional Outcomes of Adults with Cervical Spinal Cord Injuries” – Zack Ray

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“Bone Marrow Aspirate Concentration in Posterior Cervical Fusion (BMAC)” – Zack Ray

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 “Riluzole in Spinal Cord Injury Study (RISCIS)” – Zack Ray

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 “Diffusion Tensor Imaging to Assess the Functional Outcomes of Adults With Cervical Spinal Cord Injuries” – Zack Ray

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 “DuraSeal Exact Spine Sealant System Post-Approval Study (DuraSeal PAS)” – Zack Ray

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 “Pivotal IDE Study of the BRYAN(R) Cervical Disc Prosthesis in the Treatment of DDD Versus ACDF” – Zack Ray

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 “The INSPIRE Study: Probable Benefit of the Neuro- Spinal Scaffold for Treatment of AIS A Thoracic Acute Spinal Cord Injury” – Zack Ray

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Biomedical Engineering
Current Grants:

“Electrophysiological Studies of Human Attention” – Eric Leuthardt
NIH R01
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Current Clinical Trials:

“LAASR: MK-3475 in Combination With MRI-Guided Laser Ablation in Recurrent Malignant Glioma; Laser Ablation After Stereotactic Radiosurgery” – Eric Leuthardt
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“MRI-Guided Laser Surgery and Doxorubicin Hydrochloride in Treating Patients With Recurrent Glioblastoma Multiforme” – Eric Leuthardt
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“Treatment of Chronic Stroke With IpsiHand” – Eric Leuthardt
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“Laser Ablation in Stereotactic Neurosurgery (LAISE): NeuroBlate® Retrospective Registry Monteris” – Eric Leuthardt

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“Laser Ablation of Abnormal Neurological Tissue Using Robotic NeuroBlate System (LAANTERN)” – Eric Leuthardt
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Pediatric Neurosurgery
Current Grants:

“A randomized controlled trial of anterior versus posterior entry site for cerebrospinal fluid shunt insertion” – David Limbrick
PCORI Subcontract with Baylor
01/01/15 – 12/31/15
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“Posterior Fossa Decompression With or Without Duraplasty for Chiari Type I Malformation with Syringomyelia” – David Limbrick
Patient Centered Outcomes Research Institute (PCORI)
2015 for 45 months
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“MR Elastography and CSF Biomarkers in Post-Hemorrhagic Hydrocephalus” – David Limbrick
Hope Center for Neurological Disorders
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“Effects of Cerebrospinal Fluid Diversion on Functional Connectivity in Prematurely-Born Infants with Hydrocephalus”  – David Limbrick
March of Dimes Prematurity Research Center at Washington University
 
“A Pilot Study of Using MRI-Guided Laser Heat Ablation in to Induce Disruption of the Peritumoral Blood Brain Barrier and Enhance Efficacy of Treatment for Pediatric Brain Tumors”  – David Limbrick
Children’s Discovery Institute
02/01/2016 – 1/31/2019
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“Gene Discovery in Syringomyelia and Chiari I Malformation”  – David Limbrick
Spinal Cord Injury/Disease Research Program
 
Current Clinical Trials:
“Posterior Fossa Decompression With or Without Duraplasty for Chiari Type I Malformation With Syringomyelia”  – David Limbrick
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“The CSF Shunt Entry Site Trial”  – David Limbrick
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Aneurysm / Cerebrovascular
Current Grants:

“Translating Endogenous Vascular Protective Cascades into Therapy for Aneurysmal Subarachnoid Hemorrhage” – Gregory Zipfel
NIH R01
09/01/15 – 08/30/20
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Education
Current Grants:

 “Washington University Neurosurgery Resident Research Education Program” – Gregory Zipfel
NIH R25
09/30/15 – 06/30/20
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