Department of  Neurosurgery
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Clinical Trials

What is a Clinical Trial?

Washington University Department of Neurosurgery Aneurysm faculty are involved with a number of ongoing studies to better treat patients with aneurysm-related pathology. These studies are designed to compare different treatment options or drugs to help improve the way we treat aneurysms. Your participation in a clinical trial is completely voluntary and will not impact the care you receive. If you decide to participate you can withdraw at any time. Only you and your physician can decide if you are eligible for a clinical trial and not all spine disorders are eligible for participation.

Why Participate?

Clinical trials offer new cutting edge treatment options and/or medications that may improve your outcome. These trials take advantage of existing standard-of-care treatment and combine new strategies to improve your individual outcome. There is no way to be sure that the new treatment will improve your specific pathology but participation will provide the opportunity to be involved with new treatment options not currently available.

How?

If you are interested in participating or learning more about your eligibility for a clinical trial, discuss with your doctor whether a clinical trial is appropriate for you.

Our Current and Pending Trials Include:

"SWIFT PRIME"
Principal Investigator — Dr. Colin Derdeyn
To determine if thrombectomy after intravenous tPA (tissue plasminogen activator) is better than tPA alone for large vessel occlusion.
Seeking patients presenting with severe acute ischemic stroke and eligible for tPA.
If you have questions or want more information, please call Bridget Filiput at 314-362-5580.

iFlow for Pipeline
Principal Investigator — Dr. Christopher Moran
To measure changes in flow dynamics after flow diversion using Siemens iFlow software to help determine which patients are more likely to be cured with the Pipeline device.
Seeking patients undergoing Pipeline flow diversion for aneurysms.
If you have questions or want more information, please call Bridget Filiput at 314-362-5580.

"HEAT"
Principal Investigator — Dr. Christopher Moran
To determine if hydrogel coated coils are better than standard bare platinum coils.
Seeking patients undergoing coil embolization of brain aneurysms.
If you have questions or want more information, please call Bridget Filiput at 314-362-5580.

"ASPIRE"
Principal Investigator — Dr. DeWitte Cross
To learn better what the risks and outcomes are via a post-market registry tracking outcomes of patients treated with the Pipeline device.
Seeking patients undergoing Pipeline flow diversion for aneurysms.
If you have questions or want more information, please call Bridget Filiput at 314-362-5580.

"FRED"
Principal Investigator — Dr. Christopher Moran
This is an FDA trial for pre-market approval of a novel flow-diverting device with some technical advantages over Pipeline.
Seeking patients undergoing FRED flow diversion for aneurysms.
If you have questions or want more information, please call Bridget Filiput at 314-362-5580.

Pipeline Aneurysm Pressures
Principal Investigator — Dr. Colin Derdeyn
To measure pressures within aneurysms before and after Pipeline flow diversion via a microcatheter placed within the aneurysm, to help us predict which patients are at risk for aneurysm rupture after treatment with flow diversion.
Seeking patients undergoing Pipeline flow diversion for aneurysms.
If you have questions or want more information, please call Bridget Filiput at 314-362-5580.

Effect of red blood cell transfusion on brain metabolism in patients with subarachnoid hemorrhage
Principal Investigator — Dr. Michael Diringer
To evaluate whether blood transfusion can improve oxygen delivery to vulnerable brain regions in patients at risk for delayed cerebral ischemia after SAH (Subarachnoid Hemorrhage).
Seeking aneurysmal SAH patients at risk for delayed cerebral ischemia or anemia.
If you have questions or want more information, please call Michelle Allen at 314-747-1884.

Microdialysis of amyloid-beta and related biomarkers in traumatic brain injury and hemorrhage
Principal Investigator — Dr. Terry Kummer
To look at protein changes in the brain that may tell us about damage that occurs after TBI (Traumatic Brain Injury) or hemorrhage via a microdialysis catheter
Seeking patients who will be having surgery for TBI or hemorrhage.
If you have questions or want more information, please call Michelle Allen at 314-747-1884.

"DOPAST"
Principal Investigator — Theresa Human-Murphy, PharmD
To compare short-duration levetiracetam to extended course of same medication after SAH (Subarachnoid Hemorrhage) to improve anti-seizure management for future SAH patients.
Seeking patients with SAH due to aneurysm rupture.
If you have questions or want more information, please call Michelle Allen at 314-747-1884.

"MISTIE III" (Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation, Phase III)
Principal Investigator — Dr. Michael Diringer
To compare Minimally Invasive Surgery (MIS) with Rt-PA (Recombinant tissue-Plasminogen Activator) treatment and standard medical management on outcomes after Intracerebral Hemorrhage (ICH).
Seeking patients with spontaneous bleeding into the brain.
If you have questions or want more information, please call Michelle Allen at 314-747-1884.

Effect of Minocycline on MMP-9 levels and vasospasm after SAH
Principal Investigator — Dr. Greg Zipfel
To assess safety and effect of minocycline on MMP-9 levels after aneurysmal subarachnoid hemorrhage.
Seeking patients with aneurysmal subarachnoid hemorrhage within 72 hours of onset.
If you have questions or want more information, please call 314-747-8882.

Effect of Sildenafil on vasospasm and cerebral bloodflow after subarachnoid hemorrhage
Principal Investigator — Dr. Greg Zipfel
To see if sildenafil improves blood flow to the brain and reduces the chances of having a stroke after subarachnoid hemorrhage from a ruptured aneurysm.
Seeking patients with subarachnoid hemorrhage due to aneurysm rupture.
If you have questions or want more information, please call 314-747-8882.

Radiologic assessment and outcomes of subarachnoid hemorrhage patients with negativeinitial cerebral angiography
Principal Investigator — Dr. Greg Zipfel
To assess characteristics of SAH of unknown etiology, treatments, and outcomes.
Seeking patients with initial cerebral angiography that is negative for aneurysm after subarachnoid hemorrhage.
If you have questions or want more information, please call 314-747-8882.

VERITAS (Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke)
Principal Investigator — Dr. Greg Zipfel
This multi-site, NIH-funded study is to assess risk for repeat stroke or TIA in patients with significant vertebrobasilar disease.
Seeking patients with posteriorcirculation stroke or TIA and vertebrobasilar disease.
If you have questions or want more information, please call 314-747-8882.