Hiroko Yano, PhD
Assistant Professor of Neurological Surgery, Neurology and Genetics
Washington University School of Medicine
Department of Neurological Surgery
660 S. Euclid Avenue
Campus Box 8057
St. Louis, Missouri 63110
Transcriptional dysregulation and mitochondrial dysfunction are thought to contribute to the pathogenesis of neurodegenerative diseases including Huntington’s disease (HD). We are trying to understand how these key cellular changes lead to neuronal death and dysfunction as well as to identify the upstream pathways that regulate these changes. We use molecular biological, cell biological, biochemical and genetic approaches and take advantage of primary neuron culture as well as cell and animal models of HD. A current major focus is the identification of novel epigenetic pathways that alter histone modifications and lead to aberrant gene expression in HD.
B.S. Department of Pharmaceutical Sciences, Tokyo University of Science (Japan), 1991
M.S. PhD program in Pharmaceutical Sciences, University of Tokyo (Japan), 1993
Ph.D. PhD program in Pharmaceutical Sciences,University of Tokyo (Japan), 1996
Instructor, Department of Neurosurgery, Brigham and Woman’s Hospital, Harvard Medical School, Boston, MA, 2008-2010
Assistant Professor, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, 2010-2012
Ad hoc Reviewer: Journal of Neurobiology, BioEssays, and FASEB Journal.
Selected Peer-Reviewed Publications
- Yano H, Wang BE, Ahmad I, Zhang J, Abo T, Nakayama J, Krempen K, Kohwi Y. Identification of (CAG)(n) and (CGG)(n) repeat-binding proteins, CAGERs expressed in mature neurons of the mouse brain. Exp Cell Res 1999, 251:388-400.
- Yano H, Cong F, Birge RB, Goff SP, and Chao MV. Association of the Abl tyrosine kinase with the Trk nerve growth factor receptor. J Neurosci Res 2000, 59:356-64.
- Yano H, Lee FS, Kong H, Chuang J, Arevalo J, Perez P, Sung C, and Chao MV. Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor. J Neurosci 2001, 21:RC125.
- Lou X*, Yano H*, Lee F, Chao MV, and Farquhar MG. (* The first two authors contributed equally to this manuscript.) GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways. Mol Biol Cell 2001, 12:615-27.
- Khursigara G, Bertin J, Yano H, Moffett H, DiStefano PS, and Chao MV. A prosurvival function for the p75 receptor death domain mediated via the caspase recruitment domain receptor-interacting protein 2. J Neurosci 2001, 21:5854-63.
- Kim AH, Yano H, Cho H, Meyer D, Monks B, Margolis B, Birnbaum M, Chao MV. Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron 2002, 35:697-709.
- Arevalo JC, Yano H, Teng KK, and Chao MV. A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein. EMBO J 2004, 23:2358-68.
- Yano H and Chao MV. Biochemical characterization of intracellular membrane compartments bearing the Trk neurotrophin receptors. Neurochemical Res 2005, 30:767-77.
- Taveggia C, Zanazzi G, Petrylak A, Yano H, Rosenbluth J, Einheber S, Xu X, Esper RM, Loeb JA, Shrager P, Chao MV, Falls DL, Role L, and Salzer JL. Neuregulin-1 Type III Determines the Ensheathment Fate of Axons. Neuron 2005, 47:681-94.
- Arevalo JC, Pereira DB, Yano H, Teng KK, and Chao MV. Identification of a switch in neurotrophin signaling by selective tyrosine phosphorylation. J Biol Chem 2006, 281:1001-7.
- Yano H, Ninan I, Zhang H, Milner TA, Arancio O, and Chao MV. BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Nat Neurosci 2006, 9:1009-18.
- Chen L, Tanriover G, Yano H, Friedlander R, Louvi A, Gunel M. Apoptotic functions of PDCD10/CCM3, the gene mutated in cerebral cavernous malformation 3. Stroke 2009, 40:1474-81.
- Yano H, Torkin R, Martin LA, Chao MV, and Teng KK. Proneurotrophin-3 is a neuronal apoptotic ligand: evidence for retrograde-directed cell killing. J Neurosci 2009, 29:14790-14802.
- Wang X, Sirianni A, Pei Z, Cormier K, Smith K, Jiang J, Zhou S, Wang H, Zhao R, Yano H, Kim JE, Li W, Kristal BS, Ferrante RJ, and Friedlander RM. The melatonin-MT1 receptor axis modulates mutant huntingtin-mediated toxicity. J Neurosci 2011, 31:14496-507.
- Yano H, Baranov SV, Baranova OV, Kim J, Pan Y, Yablonska S, Carlisle DL, Ferrante RJ, Kim AH, Friedlander RM. Inhibition of mitochondrial protein import by mutant huntingtin. Nat Neurosci 2014, 17:822-831.
- Mao DD, Gujar AD, Mahlokozera T, Chen I, Pan Y, Luo J, Brost T, Thompson EA, Turski A, Leuthardt EC, Dunn GP, Chicoine MR, Rich KM, Dowling JL, Zipfel GJ, Dacey RG, Achilefu S, Tran DD, Yano H, Kim AH. A CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-Like Cells. Cell Rep 2015, 11:1809-21.
- Pan Y, Daito T, Sasaki Y, Chung YH, Xing X, Pondugula S, Swamidass, SJ, Wang T, Kim AH, Yano H. Inhibition of DNA methyltransferases blocks mutant huntingtin-induced neurotoxicity. Sci Rep 2016, 6:31022.
Review Articles and Book Chapters
- Yano H. and Chao MV. Neurotrophin receptor structure and interactions. Pharm Acta Helv 2000, 74:253-60.
- Yano H and Chao MV. Mechanisms of neurotrophin receptor vesicular transport. J Neurobiology 2004, 58:244-57.
Society for Neuroscience