Department of  Neurosurgery
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Call Us: (314) 362-3636

Paul Santiago, MD

Professor of Neurological and Orthopedic Surgery
Co-Director, Spinal Oncology and Neurosurgical Spine Fellowship

Washington University School of Medicine
Department of Neurological Surgery
660 S. Euclid Avenue
Campus Box 8057
St. Louis, Missouri 63110

Administrative Office: 314-747-6144
Patient Appointments: 314-362-3577
Fax: 314-362-2107

Clinical Interests
General neurosurgery with a focus in spinal disorders of the craniocervical junction, cervical, thoracic and lumbar spine: degenerative disease, spondylosis, spondylolisthesis, spinal tumors, metastatic cancer, inflammatory disorders, ankylosing spondylitis, rheumatoid arthritis, infections, congenital disorders, spinal instrumentation, minimally invasive surgery, head injury and spinal cord injury.

Research Interests
Models of metastatic cancer spread to the spine and the coverings of the spinal cord.

BSc with Honors, Biology, Stanford University
Palo Alto, California
1987 – 1990

MD, Yale University School of Medicine
New Haven, Connecticut

Intern, General Surgery
University of Washington
Seattle, Washington

Resident, Neurological Surgery
University of Washington
Seattle, Washington

Specialist Registrar, Atkinson Morley's Hospital
Wimbledon, London, United Kingdom

Chief Resident, Neurological Surgery
University of Washington
Seattle, Washington

Fellow, Minimally Invasive and General Spine Surgery
University of Chicago Hospitals
Chicago, Illinois

Hospital Appointments
Barnes-Jewish Hospital
Barnes-Jewish West County Hospital
St. Louis Children’s Hospital

Medical Licensure
Illinois, Missouri, Washington

Board Certification
American Board of Neurological Surgeons (2010)


  1. Lipka JJ, Santiago P, Chan L, Reyes GR, Samuel KP, Blattner WA, Shaw GM, Hanson CV, Sninsky JJ, Foung SKH. Modified Western Blot Assay for Confirmation and Differentiation of Human T-cell Lymphotropic Virus Types I and II. J. Inf. Dis., 164: 40-3, 1991.
  2. Inoue D, Santiago P, Horne WC, Baron R. Identification of an Osteoclast Transcription Factor that Binds to the Human T-cell Leukemia Virus Type I-long Terminal Repeat Enhancer Element. J. Biol. Chem., 272: 25386-93, 1997.
  3. Schuster JM, Santiago P, Elliott JP, Grady MS, Newell DW, Winn HR. Acute Traumatic Posteroinferior Cerebellar Artery Aneurysms: report of three cases. Neurosurgery, 45: 1465-7; discussion 1467-8, 1999.
  4. Fukuhara T, McKhann GM, 2nd, Santiago P, Eskridge JM, Loeser JD, Winn HR. Resolution of Central Pain after Embolization of an Arteriovenous Malformation. Case report. J Neurosurg, 90: 575-9, 1999.
  5. Mesiwala AH, Farrell L, Santiago P, Ghatan S, Silbergeld DL. The effects of Hydrogen Peroxide on Brain and Brain Tumors. Surg Neurol, 59: 398-407, 2003.
  6. Mourad P, Farrell L, Stamps L, Santiago P, Fillmore H, Broaddus W, Silbergeld D: Quantitative Assessment of Glioblastoma Invasion in vivo. Cancer Letters, 192: 97-107, 2003.
  7. Mohit AA, Santiago P, Rostomily R. Intramedullary tuberculoma mimicking primary CNS lymphoma. J Neuol Neurosurg Psychiatry. 75: 1636-8, 2004.
  8. Santiago P, Fessler RG. Minimally invasive surgery for the management of cervical spondylosis. Neurosurgery. 2007 Jan;60(1 Supp1 1):S160-5.
  9. Sandhu FA, Santiago P, Palmer S, Fessler RG. Minimally Invasive Surgical Treatment of Synovial Cysts. Neurosurgery. 54:107-11, 2004.
  10. Isaacs RE, Podichetty VK, Sandhu FA, Santiago P, Spears JD, Aaronson O, Kelly K, Hrubes M, Fessler RG. Thoracic Microendoscopic Discectomy: a Human Cadaver Study. Spine. 15:1226-31, 2005.
  11. Ashley WW Jr, Rivet D, Cross DT 3rd, Santiago P. Development of a giant cervical vertebral artery pseudoaneurysm after a traumatic C1 fracture: case illustration. Surg Neurol. 2006 Jul;66(1):80-1. 
  12. Rosen DS, Tredway TL, Santiago P and Fessler RG: Minimally Invasive Resection of a Spinal Epidural Cavernous Hemangioma. Japanese Journal of Spine Surgery. In press 2005.
  13. Tredway TL, Santiago P, Hrubes MR, Song JK, Christie SD, Fessler RG. Minimally invasive resection of intradural-extramedullary spinal neoplasms. Neurosurgery 58[ONS Supple1]:ONS-52—ONS-58, 2006.