Department of  Neurosurgery
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Albert H. Kim MD PhD

Albert H. Kim MD PhDAssociate Professor of Neurological Surgery, Neurology, and Developmental Biology
Surgical Director, Pituitary Center
Co-Leader, Neuro-Oncology Research Focus Group, Siteman Cancer Center
Co-Leader, Neurorestorative Therapy Group, Hope Center

Washington University School of Medicine
Department of Neurological Surgery
660 S. Euclid Avenue
Campus Box 8057
St. Louis, Missouri 63110 U.S.A.

Administrative Office: 314-747-6141
Patient Appointments: 314-362-3577
Fax: 314-362-2107

Clinical Interests:

The management of malignant and benign brain tumors using both open and minimally invasive approaches such as endoscopic techniques, interstitial laser therapy, and Gamma Knife radiosurgery. Expertise in many brain tumor types including glioblastoma, glioma, astrocytoma, oligodendroglioma, meningioma, pituitary tumors, acoustic neuromas, craniofacial tumors, and skull base tumors, such as chordomas and chondrosarcomas.

See Washington University School of Medicine press release: Scientists find way to disrupt brain tumor stem cells

Research Interests:
Malignant brain tumors continue to be challenging and devastating neurological diseases. Recent genome-wide surveys of genetic and epigenetic alterations in brain tumors has led to the identification of a multitude of tumor-specific abnormalities, but whether these molecular changes impact all tumor cells the same way is unknown. My laboratory is interested in the molecular abnormalities that specifically drive an important subset of cancer cells called brain cancer stem cells, which are thought to represent the cellular substrate for cancer recurrence. Discovery of cancer stem cell-specific vulnerabilities has the potential to lead to the development of novel therapeutic strategies for malignant brain tumors. See Kim Laboratory website.

Education:
AB, East Asian Studies
Harvard University
Cambridge, MA
1990-1994

AM, Biology/Biomedical Science
Washington University School of Medicine
St. Louis, MO
1995-1999

MD-PhD, New York University School of Medicine
New York, NY
1999-2003

Residency:
Intern in Neurosurgery/General Surgery
Brigham and Women's Hospital
Boston, MA
2003-2004

Resident in Neurosurgery
Brigham and Women's Hospital
Boston, MA
2004-2009

Chief Resident in Neurosurgery
Brigham and Women's Hospital
Boston, MA
2009-2010

Fellowship:
Cerebrovascular and Skull Base Fellow in Neurosurgery
Jackson Memorial Hospital
Miami, FL
2010-2011

Hospital Appointments:
Barnes-Jewish Hospital

Medical Licensure:
Missouri, Massachusetts

Board Certification:
American Board of Neurological Surgeons (2015)

Publications:

  1. Kim, A., Roffler-Tarlov, S., and Lin, C.S., New technique for precise alignment of an RNA differential display gel with its film image. Biotechniques, 1995. 19(3): p. 346.
  2. Kong, H., Kim, A.H., Orlinick, J.R., and Chao, M.V., A comparison of the cytoplasmic domains of the Fas receptor and the p75 neurotrophin receptor. Cell Death Differ, 1999. 6(11): p. 1133-42.
  3. Kim, A.H., Sheline, C.T., Tian, M., Higashi, T., McMahon, R.J., Cousins, R.J., and Choi, D.W., L-type Ca(2+) channel-mediated Zn(2+) toxicity and modulation by ZnT-1 in PC12 cells. Brain Res, 2000. 886(1-2): p. 99-107.
  4. Kim, A.H., Khursigara, G., Sun, X., Franke, T.F., and Chao, M.V., Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol Cell Biol, 2001. 21(3): p. 893-901.
  5. Lee, F.S., Kim, A.H., Khursigara, G., and Chao, M.V., The uniqueness of being a neurotrophin receptor. Curr Opin Neurobiol, 2001. 11(3): p. 281-6.
  6. Duntley, S.P., Kim, A.H., Silbergeld, D.L., and Miller, J.W., Characterization of the mu rhythm during rapid eye movement sleep. Clin Neurophysiol, 2001. 112(3): p. 528-31.
  7. Kim, A.H., Yano, H., Cho, H., Meyer, D., Monks, B., Margolis, B., Birnbaum, M.J., and Chao, M.V., Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron, 2002. 35(4): p. 697-709.
  8. Lee, F.S., Rajagopal, R., Kim, A.H., Chang, P.C., and Chao, M.V., Activation of Trk neurotrophin receptor signaling by pituitary adenylate cyclase-activating polypeptides. J Biol Chem, 2002. 277(11): p. 9096-102.
  9. Kim, A.H., Sasaki, T., and Chao, M.V., JNK-interacting protein 1 promotes Akt1 activation. J Biol Chem, 2003. 278(32): p. 29830-6.
  10. Kim, A.H., Maher, C.O., and Smith, E.R., Lumbar intramedullary spinal schistosomiasis presenting as progressive paraparesis: case report. Neurosurgery, 2006. 58(5): p. E996; discussion E996.
  11. Kim, A.H. and Bonni, A., Thinking within the D box: initial identification of Cdh1-APC substrates in the nervous system. Mol Cell Neurosci, 2007. 34(3): p. 281-7.
  12. Kim, A.H. and Bonni, A., Cdk1-FOXO1: a mitotic signal takes center stage in post-mitotic neurons. Cell Cycle, 2008. 7(24): p. 3819-22.
  13. Tailor, J.K., Kim, A.H., Folkerth, R.D., and Black, P.M., The development of ring-shaped contrast enhancement in a case of cerebellar dysembryoplastic neuroepithelial tumor: case report. Neurosurgery, 2008. 63(3): p. E609-10; discussion E610.
  14. Kim, A.H., Puram, S.V., Bilimoria, P.M., Ikeuchi, Y., Keough, S., Wong, M., Rowitch, D., and Bonni, A., A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons. Cell, 2009. 136(2): p. 322-36.
  15. Nagahara, A.H., Merrill, D.A., Coppola, G., Tsukada, S., Schroeder, B.E., Shaked, G.M., Wang, L., Blesch, A., Kim, A., Conner, J.M., Rockenstein, E., Chao, M.V., Koo, E.H., Geschwind, D., Masliah, E., Chiba, A.A., and Tuszynski, M.H., Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med, 2009. 15(3): p. 331-7.
  16. Yang, Y., Kim, A.H., Yamada, T., Wu, B., Bilimoria, P.M., Ikeuchi, Y., de la Iglesia, N., Shen, J., and Bonni, A., A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science, 2009. 326(5952): p. 575-8.
  17. Zada, G., Kim, A.H., Governale, L.S., and Laws, E.R., Midline filum of the sellar dura: a useful landmark during endoscopic transsphenoidal pituitary surgery. Neurosurgery, 2010. 67(2 Suppl Operative): p. 391-4.
  18. Yang, Y., Kim, A.H., and Bonni, A., The dynamic ubiquitin ligase duo: Cdh1-APC and Cdc20-APC regulate neuronal morphogenesis and connectivity. Curr Opin Neurobiol, 2010. 20(1): p. 92-9.
  19. Puram, S.V., Kim, A.H., and Bonni, A., An old dog learns new tricks: a novel function for Cdc20-APC in dendrite morphogenesis in neurons. Cell Cycle, 2010. 9(3): p. 482-5.
  20. Shankar, G.M., Chen, L., Kim, A.H., Ross, G.L., Folkerth, R.D., and Friedlander, R.M., Composite ganglioneuroma-paraganglioma of the filum terminale. J Neurosurg Spine, 2010. 12(6): p. 709-13.
  21. Puram, S.V., Kim, A.H., Ikeuchi, Y., Wilson-Grady, J.T., Merdes, A., Gygi, S.P., and Bonni, A., A CaMKIIbeta signaling pathway at the centrosome regulates dendrite patterning in the brain. Nat Neurosci, 2011. 14(8): p. 973-83.
  22. Puram, S.V., Riccio, A., Koirala, S., Ikeuchi, Y., Kim, A.H., Corfas, G., and Bonni, A., A TRPC5-regulated calcium signaling pathway controls dendrite patterning in the mammalian brain. Genes Dev, 2011. 25(24): p. 2659-73.
  23. Kim, A.H., Kasliwal, M.K., McNeish, B., Silvera, V.M., Proctor, M.R., and Smith, E.R., Features of the lumbar spine on magnetic resonance images following sectioning of filum terminale. J Neurosurg Pediatr, 2011. 8(4): p. 384-9.
  24. Kim, A.H., Governale, L.S., Kim, D.H., and Black, P.M., The management of skull base tumors. Handb Clin Neurol, 2012. 105: p. 657-64.
  25. Lin, N., Zenonos, G., Kim, A.H., Nalbach, S.V., Du, R., Frerichs, K.U., Friedlander, R.M., and Gormley, W.B., Angiogram-negative subarachnoid hemorrhage: relationship between bleeding pattern and clinical outcome. Neurocrit Care, 2012. 16(3): p. 389-98.
  26. Wong, J.M., Ziewacz, J.E., Ho, A.L., Panchmatia, J.R., Kim, A.H., Bader, A.M., Thompson, B.G., Du, R., and Gawande, A.A., Patterns in neurosurgical adverse events: open cerebrovascular neurosurgery. Neurosurg Focus, 2012. 33(5): p. E15.
  27. Puram, S.V., Kim, A.H., Park, H.Y., Anckar, J., and Bonni, A., The ubiquitin receptor S5a/Rpn10 links centrosomal proteasomes with dendrite development in the mammalian brain. Cell Rep, 2013. 4(1): p. 19-30.
  28. Brooks, M.D., Jackson, E., Warrington, N.M., Luo, J., Forys, J.T., Taylor, S., Mao, D.D., Leonard, J.R., Kim, A.H., Piwnica-Worms, D., Mitra, R.D., and Rubin, J.B., PDE7B is a novel, prognostically significant mediator of glioblastoma growth whose expression is regulated by endothelial cells. PLoS One, 2014. 9(9): p. e107397.
  29. Aum, D.J., Kim, D.H., Beaumont, T.L., Leuthardt, E.C., Dunn, G.P., and Kim, A.H., Molecular and cellular heterogeneity: the hallmark of glioblastoma. Neurosurg Focus, 2014. 37(6): p. E11.
  30. Hawasli, A.H., Kim, A.H., Dunn, G.P., Tran, D.D., and Leuthardt, E.C., Stereotactic laser ablation of high-grade gliomas. Neurosurg Focus, 2014. 37(6): p. E1.
  31. Fouke, S.J., Benzinger, T.L., Milchenko, M., LaMontagne, P., Shimony, J.S., Chicoine, M.R., Rich, K.M., Kim, A.H., Leuthardt, E.C., Keogh, B., and Marcus, D.S., The comprehensive neuro-oncology data repository (CONDR): a research infrastructure to develop and validate imaging biomarkers. Neurosurgery, 2014. 74(1): p. 88-98.
  32. Lin, A.L., Liu, J., Evans, J., Leuthardt, E.C., Rich, K.M., Dacey, R.G., Dowling, J.L., Kim, A.H., Zipfel, G.J., Grubb, R.L., Huang, J., Robinson, C.G., Simpson, J.R., Linette, G.P., Chicoine, M.R., and Tran, D.D., Codeletions at 1p and 19q predict a lower risk of pseudoprogression in oligodendrogliomas and mixed oligoastrocytomas. Neuro Oncol, 2014. 16(1): p. 123-30.
  33. Yano, H., Baranov, S.V., Baranova, O.V., Kim, J., Pan, Y., Yablonska, S., Carlisle, D.L., Ferrante, R.J., Kim, A.H., and Friedlander, R.M., Inhibition of mitochondrial protein import by mutant huntingtin. Nat Neurosci, 2014. 17(6): p. 822-31.
  34. Badiyan, S.N., Markovina, S., Simpson, J.R., Robinson, C.G., DeWees, T., Tran, D.D., Linette, G., Jalalizadeh, R., Dacey, R., Rich, K.M., Chicoine, M.R., Dowling, J.L., Leuthardt, E.C., Zipfel, G.J., Kim, A.H., and Huang, J., Radiation therapy dose escalation for glioblastoma multiforme in the era of temozolomide. Int J Radiat Oncol Biol Phys, 2014. 90(4): p. 877-85.
  35. Kim, A.H., Thompson, E.A., Governale, L.S., Santa, C., Cahll, K., Kieran, M.W., Chi, S.N., Ullrich, N.J., Scott, R.M., and Goumnerova, L.C., Recurrence after gross-total resection of low-grade pediatric brain tumors: the frequency and timing of postoperative imaging. J Neurosurg Pediatr, 2014. 14(4): p. 356-64.
  36. Sun, S.Q., Cai, C., Murphy, R.K., DeWees, T., Dacey, R.G., Grubb, R.L., Rich, K.M., Zipfel, G.J., Dowling, J.L., Leuthardt, E.C., Leonard, J.R., Evans, J., Simpson, J.R., Robinson, C.G., Perrin, R.J., Huang, J., Chicoine, M.R., and Kim, A.H., Management of atypical cranial meningiomas, part 2: predictors of progression and the role of adjuvant radiation after subtotal resection. Neurosurgery, 2014. 75(4): p. 356-63; discussion 363.
  37. Sun, S.Q., Kim, A.H., Cai, C., Murphy, R.K., DeWees, T., Sylvester, P., Dacey, R.G., Grubb, R.L., Rich, K.M., Zipfel, G.J., Dowling, J.L., Leuthardt, E.C., Leonard, J.R., Evans, J., Simpson, J.R., Robinson, C.G., Perrin, R.J., Huang, J., and Chicoine, M.R., Management of atypical cranial meningiomas, part 1: predictors of recurrence and the role of adjuvant radiation after gross total resection. Neurosurgery, 2014. 75(4): p. 347-54; discussion 354-5; quiz 355.
  38. Garsa, A.A., Badiyan, S.N., DeWees, T., Simpson, J.R., Huang, J., Drzymala, R.E., Barani, I.J., Dowling, J.L., Rich, K.M., Chicoine, M.R., Kim, A.H., Leuthardt, E.C., and Robinson, C.G., Predictors of individual tumor local control after stereotactic radiosurgery for non-small cell lung cancer brain metastases. Int J Radiat Oncol Biol Phys, 2014. 90(2): p. 407-13.
  39. Zygourakis, C.C., Vasudeva, V., Lai, P.M., Kim, A.H., Wang, H., and Du, R., Transient pupillary dilation following local papaverine application in intracranial aneurysm surgery. J Clin Neurosci, 2015. 22(4): p. 676-9.
  40. Sylvester, P.T., Evans, J.A., Zipfel, G.J., Chole, R.A., Uppaluri, R., Haughey, B.H., Getz, A.E., Silverstein, J., Rich, K.M., Kim, A.H., Dacey, R.G., and Chicoine, M.R., Combined high-field intraoperative magnetic resonance imaging and endoscopy increase extent of resection and progression-free survival for pituitary adenomas. Pituitary, 2015. 18(1): p. 72-85.
  41. Speirs, C.K., Simpson, J.R., Robinson, C.G., DeWees, T.A., Tran, D.D., Linette, G., Chicoine, M.R., Dacey, R.G., Rich, K.M., Dowling, J.L., Leuthardt, E.C., Zipfel, G.J., Kim, A.H., and Huang, J., Impact of 1p/19q codeletion and histology on outcomes of anaplastic gliomas treated with radiation therapy and temozolomide. Int J Radiat Oncol Biol Phys, 2015. 91(2): p. 268-76.
  42. Sun, S.Q., Hawasli, A.H., Huang, J., Chicoine, M.R., and Kim, A.H., An evidence-based treatment algorithm for the management of WHO Grade II and III meningiomas. Neurosurg Focus, 2015. 38(3): p. E3.
  43. Sun, S.Q., Cai, C., Ravindra, V.M., Gamble, P., Yarbrough, C.K., Dacey, R.G., Dowling, J.L., Zipfel, G.J., Wright, N.M., Santiago, P., Robinson, C.G., Schmidt, M.H., Kim, A.H., and Ray, W.Z., Simpson Grade I-III Resection of Spinal Atypical (World Health Organization Grade II) Meningiomas is Associated With Symptom Resolution and Low Recurrence. Neurosurgery, 2015.
  44. Mao, D.D., Gujar, A.D., Mahlokozera, T., Chen, I., Pan, Y., Luo, J., Brost, T., Thompson, E.A., Turski, A., Leuthardt, E.C., Dunn, G.P., Chicoine, M.R., Rich, K.M., Dowling, J.L., Zipfel, G.J., Dacey, R.G., Achilefu, S., Tran, D.D., Yano, H., and Kim, A.H., A CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-Like Cells. Cell Reports, 2015. 11: p. 1-13.

BOOK CHAPTERS

  1. G.A. Kerchner*, A.H. Kim*, and D.W. Choi. Glutamate-mediated excitotoxicity. In: P. Jonas and H. Monyer (eds) Ionotropic glutamate receptors in the CNS. Handbook of Exp Pharm Series. Springer Berlin Heidelberg New York, pp. 443-469. 1999. (*contributed equally).
  2. A.H. Kim*, G.A. Kerchner*, and D.W. Choi. Blocking excitotoxicity. In: F.W. Marcoux and D.W. Choi (eds) CNS Neuroprotection. Handbook of Exp Pharm Series. Springer Berlin Heidelberg New York, pp. 3-36. 2002. (*contributed equally).
  3. A.H. Kim and M.V. Chao. Neurotrophin signaling in development. In: R.A. Bradshaw and E.A. Dennis (eds) Handbook of Cell Signalling. Vol. 2. Elsevier: Academic Press. 2003.
  4. I.F. Dunn, A.H. Kim, and W.B. Gormley. Traumatic brain injury. In: L. Squire et al (eds) The New Encyclopedia of Neuroscience. Elsevier, 2008.
  5. A.H. Kim, M.R. Brooks, I.F. Dunn, S.F. Shaikh, and W.B. Gormley. Current concepts in the management of traumatic brain injury. In: S. Segal et al (eds) Essential Clinical Anesthesia. Cambridge University Press. Accepted.