Department of  Neurosurgery
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Thomas Beaumont, MD, PhD

Thomas Beaumont, MD, PhDPosition: PGY 7
Hometown: Detroit, MI
Medical School: Wayne State University
Undergraduate: Wayne State University

Clinical/Research Interests: Epilepsy, tumors in eloquent cortex, skull base/Neural circuit assembly, epileptogenesis, optogenetics

Hobbies: Mountaineering, sailing, flying, food and wine

Departmental Awards:
2013-2014 - Research Symposium Presentation Award – Clinical Research
2014-2015 - Research Symposium Presentation Award – Basic Science 

Grants:

  • R25 – Epigenetic regulation of hippocampal epileptogenesis
  • NRSA – Activity dependent gene expression in human epilepsy

Publications:

  • Beaumont TL, Wippold, FJ 2nd, Dacey, RG Jr:  Natural history of colloid cysts of the third ventricle. J Neurosurg (under review).
  • Beaumont TL, Godzik, J, Smyth, MD: Subependymal giant-cell astrocytoma in the absence of tuberous sclerosis complex. J Neurosurg Pediatr, 2014 (Provisionally accepted).
  • Aum DJ, Kim D, Beaumont TL, Leuthardt EC, Dunn GP, Kim AH:  Mollecular and Cellular Heterogeneity: the Hallmark of Glioblastoma: Neurosurg Focus, Dec 2014 (in press)
  • Hawasli, AH, Beaumont TL, Vogel, TW, Woo, A, Leonard, JA:  Acalavaria: Case Illustration. J Neurosurg Pediatr, June 13: 1-13, 2014
  • Beaumont TL, Yao B, Shah AK, Kapatos, G, Loeb JA: Layer-specific CREB target gene induction in human neocortical epilepsy. J. Neurosci 2012 10; 32(41) 14389-401.
  • Beaumont TL, Limbrick, DD, Smyth, MD: Advances in the management of subependymal giant cell astrocytoma. Childs Nerv Syst 28(7):963-8, 2012.
  • Beaumont T, Kupsky WJ, Barger GR, and Sloan AE: Gliosarcoma with Multiple Extracranial Metastases: Case Report and Review of the Literature.  J. Neurooncol 83(1):39-46, 2007. 
  • Rakhade SN, Yao B, Ahmed S, Beaumont T, Shah A, Draghici S, Krauss R, Chugani HT, Sood S, Loeb JA, , A common pattern of persistent gene activation in human neocortical epileptic foci. Ann Neurol  58:736-47, 2005.
  • Dore-Duffy P, Balabanov R, Beaumont T, Katar M: The CNS Pericyte Response to Low Oxygen: Early Synthesis of Cyclopentatnone Prostaglandin of the J-Series. Microvasc Res 69:79-88, 2005.
  • Balabanov R, Lisak D, Beaumont T, Lisak RP, and Dore-Duffy P: Expression of urokinase plasminogen activator receptor on monocytes from patients with relapsing-remitting multiple sclerosis: effect of glatiramer acetate (copolymer 1). Clin Diagn Lab Immunol 8:1196-1203, 2001.
  • Dore-Duffy P, Owen C, Balabanov R, Murphy S, Beaumont T, and Rafols JA: Pericyte migration from the vascular wall in response to traumatic brain injury. Microvasc Res 60:55-69, 2000.
  • Balabanov R, Beaumont T, and Dore-Duffy P: Role of central nervous system microvascular pericytes in activation of antigen-primed splenic T-lymphocytes. J Neurosci Res 55:578-587, 1999.
  • Dore-Duffy P, Balabanov R, Beaumont T, Hritz MA, Harik SI, and LaManna JC: Endothelial activation following prolonged hypobaric hypoxia. Microvasc Res 57:75-85, 1999.

Chapters:

  • Beaumont TL and Mittal, S. Familial tumor syndromes of the central nervous system in Textbook of Contemporary Neurosurgery. Jaypee Brothers, 1056-1096, 2012.
  • Loeb JAL and Beaumont TL. The design and implementation of a successful microarray experiment in Bioinformatics for systems biology.  Humana Press, 2009.

Abstracts:

  • Beaumont TL and Loeb JA: Persistent changes in PSD-95 expression, palmitoylation and synaptic targeting characterize human epileptic neocortex. 2007 Society for Neuroscience, San Diego, CA 
  • Beaumont TL, Yao B, Rakhade, SN, Shah A, Loeb JA: Persistent regional induction of CREB target genes in human epileptic neocortex revealed by transcriptome analysis. Curing Epilepsy 2007, NIH/NINDS, Bethesda MD 
  • Beaumont TL, Rakhade, SN, Ahmed, S, Yao B, Shah A, Loeb JA : Genome-wide transcriptional analysis of human epileptic neocortex implicates modulators of synaptic potentiation. Gordon Research Conference, 2006, Colby College, Waterville, ME
  • Beaumont TL, Yao B, Ahmed S, Suwa, K, Asano E, Shah A, Loeb JA: Activity-Dependent Gene Expression Profiles in Human Neocortical Epilepsy Implicate Modulators of Glutamatergic Synaptic Strength. 2005 Society for Neuroscience, Washington DC
  • Beaumont, T and Sloan, AE: Molecular Classification of Malignant Gliomas: Distinct Subtypes Identified by Gene Expression Profiling, 2003.  Wayne State University School of Medicine Research Symposium
  • Dore-Duffy, P., Beaumont, T, and Sloan, AE: Central Nervous System Microvascular Pericyte Production of VEGF in Human Glioblastoma.  ANN  NEUROL 48 (3): 248  2000.
  • Dore-Duffy P, Balabanov R, Beaumont T: Functional differentiation of central nervous system microvascular pericytes in response T1-weighted and T2-weighted cytokines. ANN  NEUROL 44 (3): T199 1998.
  • Dore-Duffy, P., Beaumont, T. and Bullock, R: Cytokines in Traumatic Brain Injury. Journal of Neurotrauma. 14(10):A39, 1997.