Washington University School of Medicine Logowustl.edu

Hans H. Dietrich, PhD

Assistant Professor of Neurological Surgery

Washington University School of Medicine
Department of Neurological Surgery
660 S. Euclid Avenue
Campus Box 8057
St. Louis, Missouri 63110

Phone: 314-362-3648
Fax: 314-362-2107
Email: DietrichH@wudosis.wustl.edu

Research Interests
Regulatory mechanisms of cerebrovascular microcirculation; studies in the role of purinergic regulation in microvascular regulation and adjustment of local microvascular flow. Recent addition to Dr. Dietrich’s research interests include mechanism of amyloid beta-induced cerebrovascular dysfunction, cerebral amyloid angiopathy and vascular function in Alzheimer’s disease, cerebral microvessel and astrocyte communication, calcium-independent phospholipase A2b (iPLA2b) and vascular regulation. Radial and longitudinal microvascular communication; endothelial and smooth muscular interaction in physiological and in pathophysiological conditions such as hypoxia/reoxygenation or subarachnoid hemorrhage. Transduction of nitric oxide synthase and effect of NO substitution on cerebral vasospasm. For more information, go to Dacey/Dietrich Lab.

Education
B.Sc. Biology, Ruhr-University, Bochum, Germany (1979)
M.Sc. Biology (Zoology, Botany, Immunology), Ruhr-University, Bochum, Germany (1983)
Ph.D. Physiology, Max-Planck-Institute, Dortmund and Ruhr-University, Bochum, Germany (1986)

Academic Positions
Postdoctoral Research Fellowship, Department of Medical Biophysics, University of Western Ontario, London, Ontario. (1987-90)
Research Scientist, Robarts Research Institute, London, Ontario. (1989-90)
Approval by the Promotion and Tenure Committee for the appointment as Assistant Professor in the Department of Medical Biophysics (1990)
Research Associate, Department of Neurosurgery, Washington University, St. Louis, Missouri. (1991-1997)
Research Assistant Professor in Neurological Surgery (1997-2006)
Assistant Professor (2006-now)

Publications
(i) Theses

1. Dietrich, H.H. 1983.
The effect and effectiveness of epinephrine and norepinephrine on mesenteriale microvessels of the frog. (German) B.Sc. Thesis, Ruhr-University, Bochum.
2. Dietrich, H.H. 1986.
Studies on the influence of epinephrine and norepinephrine on the capillary blood flow in rat and frog mesentery. (German) Ph.D. Thesis, Ruhr-University, Bochum

(ii) Papers

  1. Dietrich, H. H., H. Weigelt, and D. W. LÙbbers. Neural and transmitter influence on the capillary diameter in exteriorized frog mesentery. Adv. Exp. Med. Biol. 180: 701-709, 1984.
  2. Dietrich, H. H. and H. Weigelt. Effect of adrenaline on capillary diameter in the frog mesentery. Adv. Exp. Med. Biol. 169: 747-753, 1984.
  3. Wolff, E. K. and H. H. Dietrich. In vivo micro application of adrenaline to capillaries in frog mesentery. Microcirc. Endoth. Lymphatics 2: 607-615, 1985.
  4. Dietrich, H. H. Effect of locally applied epinephrine and norepinephrine on blood flow and diameter in capillaries of rat mesentery. Microvasc. Res. 38: 125-135, 1989.
  5. Potter, R. F., O. Mathieu-Costello, H. H. Dietrich, and A. C. Groom. Unusual capillary network geometry in a skeletal muscle, as seen in microcorrosion casts of M. pectoralis of pigeon. Microvasc. Res. 41: 126-132, 1991.
  6. Dietrich, H. H. and K. Tyml. Microvascular flow response to localized application of norepinephrine on capillaries in rat and frog skeletal muscle. Microvasc. Res. 43: 73-86, 1992.
  7. Dietrich, H. H. and K. Tyml. Capillary as a communicating medium in the microvasculature. Microvasc. Res. 43: 87-99, 1992.
  8. Kimura, M., H. H. Dietrich, V. H. Huxley, D. R. Reichner, and R. G. Dacey, Jr.. Measurement of hydraulic conductivity in isolated arterioles of rat brain cortex. Am. J. Physiol. 264: H1788-H1797, 1993.
  9. Potter, R. F., H. H. Dietrich, K. Tyml, C. G. Ellis, J. Cronkwright, and A. C. Groom. Ischemia-reperfusion induced microvascular dysfunction in skeletal muscle: application of intravital video microscopy. Int. J. Microcirc.: Clin. Exp. 13: 173-186, 1993.
  10. Dietrich, H. H. and R. G. Dacey, Jr.. Extravascular acidification leads to hyperpolarization and dilation and extravascular alkalinization leads to constriction and depolarization in rat cerebral arterioles in vitro. J. Neurosurg. 81: 437-442, 1994.
  11. Dietrich, H. H., M. Kimura, and R. G. Dacey, Jr.. N omega-nitro-L-arginine constricts cerebral arterioles without increasing intracellular calcium levels. Am. J. Physiol. 266: H1681-H1686, 1994.
  12. Kimura, M., Dietrich, H. H., and R. G. Dacey, Jr.. Nitric oxide regulates cerebral arteriolar tone. Stroke 25: 2227-2234, 1994.
  13. Derdyn, C. P., C. J. Moran, H. H. Dietrich, and R. G. Dacey, Jr.. Polyvinyl alcohol particle size and suspension characteristics. AJNR 16: 1335-1343, 1995.
  14. Ellsworth, M. L., T. Forrester, C. G. Ellis, and H. H. Dietrich. The erythrocyte as a regulator of vascular tone. Am. J. Physiol. Heart Circ. Physiol. 269:H2155-H2161, 1995.
  15. Dietrich, H. H., Y. Kajita, and R. G. Dacey, Jr.. Local and propagated vasomotor responses in isolated rat cerebral arterioles. Am. J. Physiol. Heart Circ. Physiol. 40: H1109-H1116, 1996.
  16. Kajita, Y., H. H. Dietrich, and R. G. Dacey, Jr.. Effects of oxyhemoglobin on propagated vasodilatory response in rat cerebral arterioles. J. Neurosurg. 85: 908-916, 1996.
  17. Dacey, R.G. and Dietrich, H.H. Effect of p-2-purinoceptor antagonists on hemolysate-induced and adenosine 5'-triphosphate-induced contractions of dog basilar artery in vitro – Comment. Neurosurgery 39:822, 1996.
  18. Kajita, Y., M. Takayasu, Y. Mori, H. H. Dietrich, and R. G. Dacey,Jr.. Role of nitric oxide in autoregulatory response in rat intracerebral arterioles. Neurosurgery 42: 834-842, 1998.
  19. Dacey, R.G., Jr. and Dietrich, H.H. Effect of N-methyl-D-aspartate and inhibition of neuronal nitric oxide on collateral cerebral blood flow after middle cerebral artery occlusion – Comment. Neurosurgery 42:124, 1998.
  20. Dietrich, H.H., M.L. Ellsworth, R.S. Sprague, and R.G. Dacey, Jr. Red blood cell regulation of microvascular tone through adenosine triphosphate. Am.J.Physiol. 278: H1294-H1298, 2000.
  21. Dietrich, H. H. Extracellular ph, Ca(2+) influx, and response of vascular smooth muscle cells to 5-droxytryptamine – COMMENT. Stroke 2000 Oct ;31(10):2500-7 31: 2500-7: 2000.
  22. Dietrich, H. H. and R. G. Dacey. Molecular keys to the problems of cerebral vasospasm. Neurosurgery 46: 517-530, 2000.
  23. Horiuchi, T., H. H. Dietrich, S. Tsugane, and R. G. Dacey, Jr. Analysis of purine- and pyrimidine-induced vascular responses in the isolated rat cerebral arteriole. American Journal of Physiology – Heart & Circulatory Physiology 280: H767 - H776, 2001.
  24. Horiuchi, T., H. H. Dietrich, S. Tsugane, and R. G. Dacey, Jr. Role of potassium channels in regulation of brain arteriolar tone: Comparison of cerebrum versus brain stem. Stroke 32: 218-224, 2001.
  25. Kajita, Y., H. H. Dietrich, and R. G. Dacey, Jr. Basic fibroblast growth factor induces dilation of isolated intracerebral arterioles in rats: Role of membrane hyperpolarization. Neurologica Medico-chirurgica, 41: 177-186, 2001.
  26. Horiuchi, T., H. H. Dietrich, K. Hongo, S. Tsugane, and R. G. Dacey, Jr. Role of endothelial nitric oxide and smooth muscle potassium channel in cerebral arteriolar dilation to acidosis. Stroke 33:844-849, 2002.
  27. Horiuchi, T., H. H. Dietrich, K. Hongo, S. Tsugane, and R. G. Dacey, Jr. Mechanism of Extracellular K+-induced local and conducted responses in cerebral penetrating arterioles. Stroke 33: 2692-2699, 2002.
  28. H. H. Dietrich, M. L. Ellsworth, and R. G. Dacey, Jr. The red blood cell, ATP and integrated vascular responses to neuronal stimulation. Excerpta Medica 1235:277-287, 2002.
  29. T. Horiuchi, H. H. Dietrich, K. Hongo, and R. G. Dacey, Jr. Comparison of purinoceptor subtypes producing dilation in rat intracerebral arterioles. Stroke 2003 June;34(6):1473-8.
  30. Dietrich HH, Dacey RG, Jr. and Xiang C. Rescue of Hypoxia/Reoxygenation Induced Impaired Dilation in Rat Cerebral Arterioles. 8th World Congress for Microcirculation. J. H. Lombard, Edt. Medimond S.r.l. ISBN 978-88-7587-373-8:191-195, 2007.
  31. H. H. Dietrich, T. Horiuchi, C. Xiang, K. Hongo, J. R. Falck, and R. G. Dacey, Jr. Mechanism of ATP-induced local and conducted vasomotor responses in isolated rat cerebral penetrating arterioles. Journal of Vascular Research 46:253-264, 2008.
  32. B. H. Han, M.-L. Zhou, F. Abousaleh, R. P. Brendza, H. H. Dietrich, J. Koenigsknecht-Talboo, J. Cirrito, E. Milner, D. M. Holtzman, and G. J. Zipfel. Cerebrovascular dysfunction in amyloid precursor protein transgenic mice: contribution of soluble and insoluble amyloid-ß peptide, partial restoration via g-secretase inhibition. Journal of Neuroscience, 2009.
  33. S. Basak, D. Brogan, H. H. Dietrich, R. Ritter, R. G. Dacey, Jr., and P. Biswas. Transport characteristics of nanoparticle-based ferrofluids in a gel model of the brain. International Journal of Nanomedicine 4:1-18, 2009.

(iii) Review Articles

  1. H. H. Dietrich and R. G. Dacey, Jr. Molecular keys to the problems of cerebral vasospasm. Neurosurgery 46:517-530, 2000.
  2. Mary L. Ellsworth, Christopher G. Ellis, Daniel Goldman, Alan H. Stephenson, Hans H. Dietrich, and Randy S. Sprague. Erythrocytes: oxygen sensors and modulators of vascular tone in regions of low PO2. Physiology (Bethesda), 2009.