Washington University School of Medicine Logowustl.edu

David D. Limbrick, MD, PhD

Assistant Professor of Neurological Surgery and Pediatrics

Washington University School of Medicine
Department of Neurological Surgery
660 S. Euclid Avenue
Campus Box 8057
St. Louis, MO 63110

Phone: (314) 454-4630
Fax: (314) 454-2818
Email: limbrickd@wustl.edu

Clinical Interests
Pediatric neurosurgery, epilepsy surgery, neuro-endoscopy, hydrocephalus, pediatric brain tumors, deep brain stimulation, radiosurgery, pediatric spine.

Research Interests
Neuronal membrane physiology, patch-clamp electrophysiology, CSF proteomics, hydrocephalus, neuroprosthetics, brain tumor biology

Education
BS, Biology, College of William and Mary
Williamsburg, Virginia
1992-1995

MD, Medical College of Virginia, Virginia Commonwealth University
Richmond, Virginia
1995-2001

PhD, Medical College of Virginia, Virginia Commonwealth University
Richmond, Virginia
1995-2001

Residency
Intern, General Surgery
Washington University School of Medicine
St. Louis, Missouri
2001-2002

Resident, Neurological Surgery
Barnes-Jewish Hospital & Washington University School of Medicine
St. Louis, Missouri
2002-2007

Senior Registrar, Neurological Surgery
Beaumont Hospital
Dublin, Ireland
2005

Chief Resident, Neurological Surgery
Barnes-Jewish Hospital & Washington University School of Medicine
St. Louis, Missouri
2006-2007

Fellowship
Fellow, Pediatric Neurological Surgery
St. Louis Children’s Hospital & Washington University School of Medicine
St. Louis, Missouri
2007-2008

Hospital Appointments
St. Louis Children's Hospital, St. Louis, Missouri
Barnes-Jewish Hospital, St. Louis, Missouri

Medical Licensure
Missouri

Board Certification
American Board of Neurological Surgeons (2013)

Publications

  1. Limbrick, D.D.J., Churn, S.B., Sombati, S., and DeLorenzo, R.J. Inability to restore resting intracellular calcium levels as an early indicator of delayed neuronal cell death. Brain Research 690: 145-56, 1995.
  2. Churn, S.B., Limbrick, D., Sombati, S., and DeLorenzo, R.J. Excitotoxic activation of the NMDA receptor results in inhibition of calcium/calmodulin kinase II activity in cultured hippocampal neurons. Journal of Neuroscience 15: 3200-14, 1995.
  3. DeLorenzo, R.J. and Limbrick, D.D.J. Effects of glutamate on calcium influx and sequestration/extrusion mechanisms in hippocampal neurons. Advances in Neurology 71: 37-46, 1996.
  4. Pal, S., Sombati, S., Limbrick, D.D.J., and DeLorenzo, R.J. In vitro status epilepticus causes sustained elevation of intracellular calcium levels in hippocampal neurons. Brain Research 851: 20-31, 1999.
  5. Pal, S., Limbrick, D.D.J., Rafiq, A., and DeLorenzo, R.J. Induction of spontaneous recurrent epileptiform discharges causes long-term changes in intracellular calcium homeostatic mechanisms. Cell Calcium 28: 181-93, 2000.
  6. Limbrick, D.D.J., Pal, S., and DeLorenzo, R.J. Hippocampal neurons exhibit both persistent Ca2+ influx and impairment of Ca2+ sequestration/extrusion mechanisms following excitotoxic glutamate exposure. Brain Research 894: 56-67, 2001.
  7. Pal, S., Sun, D., Limbrick, D., Rafiq, A., and DeLorenzo, R.J. Epileptogenesis induces long-term alterations in intracellular calcium release and sequestration mechanisms in the hippocampal neuronal culture model of epilepsy. Cell Calcium 30: 285-96, 2001.
  8. Limbrick, D.D.J., Sombati, S., and DeLorenzo, R.J. Calcium influx constitutes the ionic basis for glutamate-induced extended neuronal depolarization in hippocampal neurons. Cell Calcium 33:69-81, 2003.
  9. Limbrick, D.D.J., Wright, N.M. Verification of nerve root decompression during minimally-invasive lumbar microdiskectomy: a practical application of surgeon-driven evoked EMG. Minimally Invasive Neurosurgery 48: 273-7, 2005.
  10. Limbrick, D.D.J. and Park, T.S. Occult hydrocephalus in children with cerebral palsy. Neurosurgery 58(3):E590, 2006.
  11. Mangano, F.T., Limbrick, D.D.J., Leonard, J.R., Park, T.S., and Smyth, M.D. Simultaneous image-guided and endoscopic navigation (SIGEN) without rigid skull fixation: application in infants: technical case report. Neurosurgery 58: ONS-E377, 2006.
  12. Smyth, M.D, Limbrick, D.D.J., Ojemann, J.G., Zempel, J., Robinson, S., O’Brien, D.F., Saneto, R.P., Goyal, M., Appleton R.E., Mangano, F.T., and Park, T.S. Surgical outcomes for temporal lobe epilepsy and hippocampal sclerosis in young children. Journal of Neurosurgery 106:205-10, 2007.
  13. Deshpande, L.S., Limbrick, D.D., Sombati, S., and Delorenzo, R.J. Activation of a novel injury-induced calcium permeable channel that plays a key role in causing extended neuronal depolarization and initiating neuronal death in excitotoxic neuronal injury. Journal of Pharmacology and Experimental Therapeutics 322:443-52, 2007.
  14. Schalk, G., Kubanek, J., Miller, K.J., Anderson, N.R., Leuthardt, E.C., Ojemann, J.G., Limbrick, D., Moran, D., Gerhardt, L.A., and Wolpaw, J.R. Decoding two-dimensional movement trajectories using electrocorticography signals in humans. Journal of Neural Engineering 4:264-75, 2007.
  15. Limbrick, D.D.J., Leonard, J.C., Wright, N.M., Leonard, J.R. Cervical Spine Trauma in Children, Including Spinal Cord Injury Without Radiographic Abnormality, in Kim, D., Betz, R., Huhn, S., and Newton, P. (eds) Surgery of the Pediatric Spine. Thieme Medical Publishers, New York, 2008, p.489-500.
  16. Limbrick, D.D.J., Lusis, E.A., Chicoine, M.R., Simpson, J.R., Rich, K.M., Dacey, R.G., Dowling, J.L., Grubb, R.L., Filiput, E.A., Drzymala, R.E., Mansur, D.B., and Malyapa, R.S. Combined surgical resection and stereotactic radiosurgery for treatment of cerebral metastases. Surgical Neurology 2008 Apr 17. [Epub ahead of print].
  17. Kiehl, E., Stojadinovic, S., Malinowski, K.T., Limbrick, D., Jost, S.C., Rubin J.B., Deasy, J.O., Parikh, P.J., Lowe, D.A., and Hope, A.J. microRT: CNS Radiotherapy. Medical Physics 35: 4735-43, 2008.
  18. Miller, J.H., Limbrick, D.D.J., Callen, M., and Smyth M.D. Spontaneous resolution of Chiari type I malformation in monozygotic twins. J Neurosurg Peds 2: 317-19, 2008.
  19. Goldhoff, P.*, Warrington, N.*, Limbrick, D.D.J.*, Hope, A., Woerner, B.M., Jackson, E., Perry, A., Piwnica-Worms, D., and Rubin, J.B. Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression. Clin Cancer Res 12: 7717-25, 2008.
  20. Behdad, A.,* Limbrick, D.D.J.,* and Smyth, M.D. Epilepsy surgery in children with seizures arising from the Rolandic cortex. Epilepsia. In press.
  21. Lipira, A., Limbrick, D., Haughey, B., Custer, P., and Chicoine, M. Titanium mesh reconstruction to maintain scalp contour after temporalis musculo-fascial flap reconstruction of middle fossa floor: A technical note and report of two cases. Skull Base. In press.
  22. Johnston, J.M., Limbrick, D.D.J., Ray, W.Z. and Park, T.S. Isolated cerebellar Rosai-Dorfman granuloma mimicking Lhermitte-DuClos: Case presentation and review of the literature. J Neurosurg Peds. In press.
  23. Limbrick, D.D.J., Behdad, A., Derdeyn, C.P., Zipfel, G.J., and Santiago, P. Traumatic avulsion of the ophthalmic artery mimics aneurysmal subarachnoid hemorrhage and clinical course. Journal of Neurosurgery. In press.
  24. Limbrick, D.D.J., Narayan, P., Powers, A.K., Ojemann, J.G., Park, T.S., Bertrand, M., and Smyth, M.D. Hemispherotomy: Efficacy and analysis of seizure recurrence. J Neurosurg Peds. In press.