Washington University School of Medicine Logowustl.edu

Albert H. Kim MD PhD

Assistant Professor of Neurological Surgery, Neurology, and Developmental Biology

Washington University School of Medicine
Department of Neurological Surgery
660 S. Euclid Avenue
Campus Box 8057
St. Louis, Missouri 63110 U.S.A.

Patient Appointments: 314-362-3577
Fax: 314-362-2107
e-mail: kima@wudosis.wustl.edu


Clinical Interests:
Brain tumors (using both open and minimally invasive approaches), including glioblastoma, glioma, astrocytoma, oligodendroglioma, meningioma, pituitary tumors, acoustic neuromas, craniofacial tumors, skull base tumors, and Gamma Knife.

Research Interests:
Despite advances in multimodal therapies, malignant brain tumors continue to be devastating neurological diseases. The proliferation of recent genome-wide surveys of genetic and epigenetic alterations in brain tumors has led to the important identification of a multitude of tumor-specific abnormalities, which are only beginning to be understood at the functional, biological level. The goal of my laboratory is to use a combined genomic and developmental approach to identify critical signaling nodes that drive malignant brain tumor growth and invasiveness. The underlying hypothesis of the research is that abnormalities in processes that govern normal neural development contribute to malignant transformation and behavior. My laboratory therefore focuses on common signaling pathways in brain development and malignant brain tumors, with an emphasis on glioblastoma multiforme and medulloblastoma. Potentially, these discoveries could be leveraged clinically to generate novel therapies for patients. See Kim Laboratory website.

Education:
AB, East Asian Studies
Harvard University
Cambridge, MA
1990-1994

AM, Biology/Biomedical Science
Washington University School of Medicine
St. Louis, MO
1995-1999

MD-PhD, New York University School of Medicine
New York, NY
1999-2003

Residency:
Intern in Neurosurgery/General Surgery
Brigham and Women's Hospital
Boston, MA
2003-2004

Resident in Neurosurgery
Brigham and Women's Hospital
Boston, MA
2004-2009

Chief Resident in Neurosurgery
Brigham and Women's Hospital
Boston, MA
2009-2010

Fellowship:
Cerebrovascular and Skull Base Fellow in Neurosurgery
Jackson Memorial Hospital
Miami, FL
2010-2011

Hospital Appointments:
Barnes-Jewish Hospital

Medical Licensure:
Missouri, Massachusetts

Board Certification:
Board Eligible

Publications:

  1. A. Kim, S. Roffler-Tarlov, and C.S. Lin. New technique for precise alignment of an RNA differential display gel with its film image. Biotechniques 19:346. 1995.
  2. C. Ayata, G. Ayata, H. Hara, R.T. Matthews, M.F. Beal, R.J. Ferrante, M. Endres, A. Kim, R.H. Christie, C. Waeber, P. Huang, B.T. Hyman, and M.A. Moskowitz. Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice. J Neuroscience 17(18):6908-6917. 1997.
  3. H. Kong*, A.H. Kim*, J. Orlinick, and M.V. Chao. A comparison of the cytoplasmic death domains of the p75 neurotrophin receptor and the Fas receptor. Cell Death Differ 6(11):1133-42. 1999. (*contributed equally).
  4. A.H. Kim, C.T. Sheline, M. Tian, T. Higashi, R.J. McMahon, R.J. Cousins, and D.W. Choi. L-type Ca2+ channel-mediated Zn2+ toxicity and modulation by ZnT-1 in PC12 cells. Brain Res 886(1-2):99-107. 2000.
  5. A.H. Kim, G. Khursigara, X. Sun, T.F. Franke, and M.V. Chao. Akt phosphorylates and negatively regulates Apoptosis signal-regulating kinase 1. Mol Cell Bio 21(3):893-901. 2001.
  6. S.P. Duntley, A.H. Kim, D.L. Silbergeld, and J.W. Miller. Characterization of the mu rhythm during rapid eye movement sleep. Clin Neurophysiol 112(3):528-31. 2001.
  7. F.S. Lee, A.H. Kim, G. Khursigara, and M.V. Chao. The uniqueness of being a neurotrophin receptor. Curr Opin Neurobiol 11(3):281-6. 2001.
  8. F.S. Lee, R. Rajagopal, A.H. Kim, P.C. Chang, and M.V. Chao. Activation of Trk neurotrophin receptor signaling by Pituitary Adenylate Cyclase-Activating Polypeptides (PACAPs). J Biol Chem 277(11):9096-102. 2002.
  9. A.H. Kim, H. Yano, H. Cho, D. Meyer, B. Monks, B. Margolis, M.J. Birnbaum, and M.V. Chao. Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron 35(4): 697-709. 2002.
  10. A.H. Kim, T. Sasaki, and M.V. Chao. JNK-interacting protein 1 promotes Akt1 activation. J Biol Chem 278(32): 29830-6. 2003.
  11. A.H. Kim, C.O. Maher, and E.R. Smith. Lumbar Intramedullary Spinal Schistosomiasis Presenting As Progressive Paraparesis: A Case Report. Neurosurgery. 58(5):E996. 2006.
  12. A.H. Kim and A. Bonni. Thinking within the D box: Initial identification of Cdh1-APC substrates in the nervous system. Mol Cell Neurosci. 34(3): 281-7. 2007.
  13. J.K. Tailor, A.H. Kim, R.D. Folkerth, and P.M. Black. The development of ring-shaped contrast enhancement in a case of cerebellar dysembryoplastic neuroepithelial tumour. Neurosurgery. 63(3): E609-10. 2008.
  14. A.H. Kim and A. Bonni. CDK1-FOXO1: A mitotic signal takes center stage in post-mitotic neurons. Cell Cycle. 7(24):3819-22. 2008.
  15. A.H. Kim, S.V. Puram, P.M. Bilimoria, S. Keough, M. Wong, D. Rowitch, and A. Bonni. A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons. Cell. 136(2):322-336. 2009.
  16. A.H. Nagahara, D.A. Merrill, G. Coppola, S. Tsukada, B.E. Schroeder, G.M. Shaked, L. Wang, A. Blesch, A. Kim, J.M. Conner, E. Rockenstein, M.V. Chao, E.H. Koo, D. Geschwind, E. Masliah, A.A. Chiba, and M.H. Tuszynski. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med. 15(3):331-7. 2009.
  17. Y. Yang, A.H. Kim, T. Yamada, B. Wu, P.M. Bilimoria, Y. Ikeuchi, N. de la Iglesia, J. Shen, and A. Bonni. A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science 326:575-8. 2009.
  18. Y. Yang, A.H. Kim, and A. Bonni. The Dynamic Ubiquitin Ligase Duo: Cdh1-APC and Cdc20-APC tag team to pattern the brain. Curr Opin Neurobiol. 20(1):92-9. 2010.
  19. S.V. Puram, A.H. Kim, and A. Bonni. An old dog learns new tricks: A novel function for Cdc20-APC in dendrite morphogenesis in neurons. Cell Cycle. 9(3):482-5. 2010.
  20. G.M. Shankar, L. Chen, A.H. Kim, G.L. Ross, R.D. Folkerth, and R.M. Friedlander. Composite ganglioneuroma-paraganglioma of the filum terminale. J Neurosurg: Spine. 12(6):709-13. 2010.
  21. G. Zada, A.H. Kim, L.S. Governale, and E.R. Laws. Midline filum of the sellar dura: a useful landmark during endoscopic transsphenoidal pituitary surgery. Neurosurgery 67(2 Suppl Operative):391-4. 2010.
  22. S.V. Puram, A.H. Kim, Y. Ikeuchi, A. Riccio, S. Koirala, J.T. Wilson-Grady, A. Merdes, S.P. Gygi, G. Corfas, and A. Bonni. A Unique CaMKIIβ Signaling Pathway at the Centrosome Regulates Dendrite Patterning in the Mammalian Brain. Nat Neurosci. 14(8):973-83.2011.

BOOK CHAPTERS

  1. G.A. Kerchner*, A.H. Kim*, and D.W. Choi. Glutamate-mediated excitotoxicity. In: P. Jonas and H. Monyer (eds) Ionotropic glutamate receptors in the CNS. Handbook of Exp Pharm Series. Springer Berlin Heidelberg New York, pp. 443-469. 1999. (*contributed equally).
  2. A.H. Kim*, G.A. Kerchner*, and D.W. Choi. Blocking excitotoxicity. In: F.W. Marcoux and D.W. Choi (eds) CNS Neuroprotection. Handbook of Exp Pharm Series. Springer Berlin Heidelberg New York, pp. 3-36. 2002. (*contributed equally).
  3. A.H. Kim and M.V. Chao. Neurotrophin signaling in development. In: R.A. Bradshaw and E.A. Dennis (eds) Handbook of Cell Signalling. Vol. 2. Elsevier: Academic Press. 2003.
  4. I.F. Dunn, A.H. Kim, and W.B. Gormley. Traumatic brain injury. In: L. Squire et al (eds) The New Encyclopedia of Neuroscience. Elsevier, 2008.
  5. A.H. Kim, M.R. Brooks, I.F. Dunn, S.F. Shaikh, and W.B. Gormley. Current concepts in the management of traumatic brain injury. In: S. Segal et al (eds) Essential Clinical Anesthesia. Cambridge University Press. Accepted.